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EC number: 218-524-5 | CAS number: 2172-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 August, 1993 to 10 November, 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Identification: FAT 46014 / G
- Lot/batch: 258645.16
- Purity test date: 99.8 % AS
- Apperance : Red solid - Analytical monitoring:
- yes
- Details on sampling:
- Composite samples of each test concentration were drawn by mixing identical volumes of the test solutions taken from the approximate center of the test vessels. They were taken immediately before exposure and after 48 hours exposure and kept at - 18 °C to - 22 °C until analysis.
- Vehicle:
- no
- Details on test solutions:
- Stock solution: 0.99 g test substance were mixed with 9.02 g water, containing 0.4 % ARKOPAL by means of a marble mill during 24 hours. 1.00 g of this blend were mixed and made up to 1000 ml with water.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Strain:Straus 1820
- Source:CIBA-GEIGY Ltd., testing facility
- Method of breeding:Cultures of daphnia are maintained in glass vessels containing approx. 2.5 L of reconstituted water (see below) at 20 +/- 1 °C (water is renewed partially thrice weekly). At each renewal the daphnia are fed with a suspension of green algae (Scenedesmus subspicatus) supplemented by a suspension of TETRAMIN-extract in such quantities that the food is consumed after 24 h.
- Feeding during test : None during the test
ACCLIMATION
- Acclimation period: 24 hours before the begin of the exposure reproductive daphnia are separated from the young by sieving all individuals through a 800 µm sieve. This operation is repeated 6 hours before the exposure and the young (6-24 h of age) are retained for the test. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- None
- Hardness:
- 240 mg CaC03/l.
- Test temperature:
- 20 +/ - 1 °C
- pH:
- None
- Dissolved oxygen:
- None
- Salinity:
- None
- Nominal and measured concentrations:
- Test concentrations:
Nominal: 4.3, 9.4, 20.7, 45.5 and 100 mg test substance/l
Initial: 3.5, 4.5, 7.7, 13.5 and 17.1 mg test substance/l
Controls:
Blank: water - Details on test conditions:
- TEST SYSTEM
- Test vessel:Beakers covered with watch glasses 100 ml solution per beaker
- Aeration:The water was aerated with clean air for at least 24 hours before use.
TEST MEDIUM / WATER PARAMETERS
Reconstituted water containing
65 mg NaHC03
294 mg CaCl2 • 2 H20
123 mg MgS04 • 7 H20
6 mg KCl
in 1000 ml bidistilled water.
OTHER TEST CONDITIONS
- Light intensity: Fluorescent light, 16 hours daily approx. 1500 lux
Vehicle: 3.6 mg alkylphenol-polyglycolether (ARKOPAL)/l - Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 17.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 17.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 17.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 17.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 17.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The test substance settled down during equilibration (7 hours), exposure and an uptake of test substance by the daphnids was observed (coloured animals) without effecting the daphnids therefore values are based on initial concentrations.
- Results with reference substance (positive control):
- None
- Reported statistics and error estimates:
- None
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 value was determined to be >17.1 mg/L at 48 h of exposure.
- Executive summary:
A study was performed to check the acute toxicity in aquatic invertebrates. The study was performed for the test item using species Daphnia magna. The method followed was C.2 of Commission Regulation (EC) No. 440/2008 which is compatible with OECD Guidelines for Testing of Chemicals No 202. The test was performed in compliance with Good Laboratory Practice Regulations.
The exposure time of FAT 46014 / G to daphnia magna was 24 and 48 hours. The nominal test concentrations used were 4.3, 9.4, 20.7, 45.5 and 100 mg test substance/L, which were found to correspond to initial measured concentrations of 3.5, 4.5, 7.7, 13.5 and 17.1 mg test substance/L. No immobilisation was observed at any of the exposure concentrations. Hence, the EC50 value was determined to be >17.1 mg/L at 48 h of exposure. The No Observed Effect Concentration was 17.1 mg/L at 48 h of exposure.
Reference
None
Description of key information
EC50 (48 h) of FAT 46014/G was found to be greater than 17.1 mg/l
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 17.1 mg/L
Additional information
A study was performed to check the acute toxicity in aquatic invertebrates. The study was performed for the test item using species Daphnia magna. The method followed was C.2 of Commission Regulation (EC) No. 440/2008 which is compatible with OECD Guidelines for Testing of Chemicals No 202. The test was performed in compliance with Good Laboratory Practice Regulations.
The exposure time of FAT 46014/G to daphnia magna was 48 hours. The nominal test concentrations used were 4.3, 9.4, 20.7, 45.5 and 100 mg test substance/L, which were found to correspond to initial measured concentrations of 3.5, 4.5, 7.7, 13.5 and 17.1 mg test substance/L. No immobilisation was observed at any of the exposure concentrations. Hence, the EC50 value was determined to be >17.1 mg/L at 48h of exposure. The No Observed Effect Concentration was 17.1 mg/L at 48 h of exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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