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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Study completion date: 02 April, 1984
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Principles of method if other than guideline:
Groups of 8 fish were exposed to the test substance for 48 h at 100, 200 and 1000 mg/L.
GLP compliance:
no
Specific details on test material used for the study:
Test material : FAT 46014/F
Analytical monitoring:
no
Details on sampling:
Not available
Vehicle:
not specified
Details on test solutions:
Not available
Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Details on test organisms:
TEST ORGANISM : Zebra fish
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Post exposure observation period:
None
Hardness:
None
Test temperature:
23 °C
pH:
8 - 8.2
Dissolved oxygen:
7.5 -7.8
Salinity:
None
Nominal and measured concentrations:
300 and 1000 mg/L (nominal)
Details on test conditions:
Refer "Any other information on materials and methods incl. tables".
Reference substance (positive control):
not specified
Duration:
48 h
Dose descriptor:
LC0
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
LC100
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Details on results:
No mortality was seen at the any of the exposure concentrations.
Results with reference substance (positive control):
None
Reported statistics and error estimates:
None
Sublethal observations / clinical signs:

None

Validity criteria fulfilled:
no
Conclusions:
The LC50 of FAT 46014/F in this fish acute toxicity test was determined to be >1000 mg/L.
Executive summary:

An acute fish toxicity test was performed according to equivalent or similar to OECD Guideline 203. Zebra fish, in two groups each containing 10 fish, were exposed to FAT 46014/F at 300 and 1000 mg/L. No mortality was seen at the any of the exposure concentrations. Hence, the LC50 of FAT 46014/F in this fish acute toxicity test was determined to be >1000 mg/L.

Description of key information

The 96 h LC50 to fish was determined to be >1000 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
1 000 mg/L

Additional information

A key study was conducted to determine the short-term toxicity of FAT 46014/F to fish. The test was performed according to OECD test guideline 203 using Zebra fish as test species. The 96 hr LC50 of FAT 46014/F in this fish acute toxicity test was determined to be >1000 mg/L as no mortality was observed. Further, several short term toxicity studies with FAT 46014 (FAT 46014/A, FAT 46014/B, FAT 46014/C and FAT 46014/E) were performed over the years using methodology similar to OECD Guideline 203. The trouts were used in these studies, each group containing 8 fish. The exposure conncetrations used were 100, 200 and 1000 mg/L for 48 hours. No mortality was seen any of these studies, hence, the LC50 in each case was >1000 mg/L.