N-(4-amino-9,10-dihydro-3-methoxy-9,10-dioxo-1-anthryl)benzenesulphonamide

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2008

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: EEC Directive 92/69, Part A, Methods for the determination ofphysico-chemical properties, A.I "MeltingIFreezing temperature" and A.2 "Boiling temperature" , EEC Publication No. L383, December 1992.

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 09979EB5
- Expiration date of the lot/batch: March 14,2011

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature at about 20 °C

Melting / freezing pt.:

233.3 °C

Atm. press.:

98.2 kPa

Decomposition:

yes

Decomp. temp.:

250 °C

Preliminary Tests

The DSC·curve of the preliminary test (heating rate of 20°C/min from 25 °C to 400 °C) is shown in Figure 1 of the report. An endothermic heat effect, the melting, was observed starting at 236.7 °C followed by an exothermic reaction starting at about 250 °C After the experiment, the sample had lost about 33% of its mass and a black shiny residue remained.

Main Tests

Melting Point / Melting Range

In order to determine the melting more precisely, further DSC·runs were recorded between 180 °C and 260 °C with a heating rate of 5°C/min. In the first main test run, the melting was observed at 233.2 °C, during the second main test run at 233.5 °C. During these runs, the sample lost about 6 % of its weight each and a red to black shiny melt remained.

Table: Determination of the Melting Point ofFAT 36034/G (Summary)

 

	Heating Range (°C)	Heating Rate (°C/min)	Melting Point (°C)	Melting Point (K)
Preliminary test	25 - 400	20	236.7	509.9
1^stMain Test	180 - 260	5	233.2	506.4
2^ndMain Test	180 - 260	5	233.5	506.7
Mean of melting point: Standard deviation (±):			233.3 0.2	506.6 0.2

 

The mean melting point was calculated from the bold values (onset point of the endothermic reaction). The tabulated values represent rounded results obtained by calculation using the exact raw data.

Conclusions:

The melting point of FAT 36034/G was determined to be 233.3 ± 0.2 °C.

Executive summary:

Determination of the melting point test is conducted with FAT 36034/G as per OECD 102 guideline. The melting point of FAT 36034/G was determined to be 233.3 ± 0.2 °C which is equal to 506.5 K ± 0.2 K using thermal analysis

Description of key information

The melting point of FAT 36034/G was determined to be 233.3 °C ± 0.2 °C which is equal to 506.5 K ± 0.2 K using thermal analysis.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

233 °C

Additional information

Studies performed according OECD guideline 102 showed the melting point of FAT 36034/G to be 233.3 °C ± 0.2 °C. Whereas another study performed in the year 2015 reported the melting point of FAT 36034/H to be 239 °C.