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EC number: 203-571-6 | CAS number: 108-31-6
Henry's Law constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- Henry's law constant
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Estimated by calculation
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Episuite modelling, using vapour pressure - and water solubility data from OECD SIDS (2004)
- Qualifier:
- according to guideline
- Guideline:
- other: Episuite: Henrywin v3.10
- H:
- ca. 0 Pa m³/mol
- Temp.:
- 25 °C
- Remarks on result:
- other: calculated value: 1.141 E-11 atm m3/mol
- Conclusions:
- From the water surface, the substance will not evaporate into the atmosphere.
- Executive summary:
The EPISuiteTM calculated Henry's law constant of maleic anhydride of 1.141E-11 atm-m³/mole suggests that the substance will not evaporate from water surfaces to the air.
- Endpoint:
- Henry's law constant
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Estimated by calculation
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Remarks:
- Calculated by using vapour pressure and water solubility.
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- calculated from water solubility and vapour pressure
- GLP compliance:
- no
- H:
- 0 Pa m³/mol
- Temp.:
- 25 °C
- Conclusions:
- Maleic acid will not evaporate from water surfaces.
- Executive summary:
The Henry's law constant calculated (SRC HENRYWIN v3.20) for maleic acid of 0.000001 Pa*m³/mol indicates that maleic acid will not evaporate from water surfaces.
- Endpoint:
- Henry's law constant
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Remarks:
- Estimated by calculation
- Justification for type of information:
- Upon contact with water, maleic anhydride hydrolyses rapidly (DT50 = 0.3 min), forming maleic acid (Bunton et al., 1963). This constitutes almost instantaneous abiotic degradation, particularly in comparison to the residence/transport times in the wastewater stream. Therefore, both sewage treatment plants and subsequently surface waters will be exposed to maleic acid (if at all) instead of maleic anhydride. Accordingly, read-across of environmental effects from maleic acid to maleic anhydride is justified.
- Reason / purpose for cross-reference:
- read-across source
- H:
- 0 Pa m³/mol
- Temp.:
- 25 °C
- Conclusions:
- Maleic acid will not evaporate from water surfaces.
- Executive summary:
The Henry's law constant calculated (SRC HENRYWIN v3.20) for maleic acid of 0.000001 Pa*m³/mol indicates that maleic acid will not evaporate from water surfaces.
This information for maleic acid is used in a read-across approach in the assessment of the target substance maleic anhydride. Upon contact with water, maleic anhydride hydrolyses rapidly (DT50 = 0.3 min), forming maleic acid. Therefore, read-across from maleic acid to maleic anhydride is justified.
Referenceopen allclose all
Description of key information
From the water surface, the substance will not evaporate into the atmosphere.
The calculated Henry's law constant of maleic anhydride of 1.141E-11 atm-m³/mole suggests that the substance will not evaporate from water surfaces to the air.
Key value for chemical safety assessment
- Henry's law constant (H) (in Pa m³/mol):
- 0
- at the temperature of:
- 25 °C
Additional information
The calculated Henry's law constant of maleic anhydride of 1.141E-11 atm-m³/mole suggests that the substance will not evaporate from water surfaces to the air (SRC HENRYWIN v3.10, 2009). However, since the substance rapidly hydrolyses in contact with water forming maleic acid, the product of hydrolysis should be considered when evaluating the fugacity of the substance. The Henry's law constant calculated for maleic acid of 0.000001 Pa*m³/mol indicates that maleic acid will not evaporate from water surfaces (SRC HENRYWIN v3.20, BASF 2009).
Maleic anhydride and maleic acid are readily biodegraded under aerobic conditions in sewage sludge, and are expected to biodegrade in soil and water as well. Fugacity-based fate and transport modelling suggest that maleic anhydride, hydrolyzed to maleic acid in water and under humid conditions, will partition primarily to water. Level III fugacity modelling indicates water as the primary compartment for distribution (air 0.3%, water 59%, soil 40.6%, sediment 0.02%) (OECD, 2004).
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