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EC number: 202-319-2
CAS number: 94-28-0
1) WoE: Short-term fish test (Fathead minnow); limit test; 1977; no OECD guideline (Eastman's internal method); predates GLP; LC50 (mortality, 96h) > 97 mg/L (nominal)2) WoE: Short-term fish test (Danio rerio); limit test; 1994; EU method C.1; GLP; LC50 (mortality, 96h) > 78 mg/L (nominal, based on DOC)
The first acute study (Fathead minnow) (Hirsch, 1979) was not
performed according to any specific guideline. This limit test did not
show any toxicity up to 97 mg/L test substance (nominal concentration).
The second test (Danio rerio) (Scholz, 1994) was performed
according to the EU method C1 and GLP standards, however this was also a
limit test. No toxicity was shown up to 78 mg/L test substance (nominal
concentration, based on measured DOC levels). Although both tests have
restrictions, they provide sufficient information to assess the absence
of acute toxicity and therefore it is believed that a weight of evidence
approach is most appropriate.
Both tests are limit tests, consequently no clear dose response curve
could be established. Additionally, the described concentrations are
well above the water solubility of the substance and therefore the test
results need to be treated with caution. Nevertheless, the results of
both tests do not indicate any toxicity up to 78 mg/L test substance.
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