Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-319-2
CAS number: 94-28-0
Oral: LD50 > 2000 mg/kg bw for rat (limit test) (OECD 420).Dermal: LD50 > 2000 mg/kg bw for rabbit (limit test) (OECD 402).Inhalation: LC50 > 2000 mg/m³ (limit test)
A key study for acute oral
toxicity was conducted according to OECD 420 and GLP guidelines in
female Sprague-Dawley rats at a dose level of 2000 mg/kg (Sanders,
2007a). There were no deaths, nor any signs of
systemic toxicity. The acute oral median lethal dose (LD50) was greater
than 2000 mg/kg body weight.
A key study for acute inhalation
toxicity was conducted in male and female Sprague-Dawley rats by 4-hour
nose-only exposure to 2000+560 mg/m³ under GLP conditions
(Dupont, 2005). No notable clinical signs of toxicity were observed in
animals immediately following exposure and no animals died. Under the
conditions of exposure, the approximate lethal concentration (ALC) and
the median lethal concentration are greater than 2000 mg/m³ air.
Additional weight of evidence was found in literature, however there
were no data on concentration nor were there details on the materials
and methods (Klimisch score 4). These data were therefore not used for
Finally, a key study for
acute dermal toxicity was conducted in male and female Sprague-Dawley
rats according to OECD 402 and GLP guidelines (Sanders, 2007b). A
24-hour, semi-occluded dermal application of the undiluted test material
applied to intact skin at a dose level of 2000 mg/kg bodyweight.
Clinical signs and bodyweight development were monitored during the
were no deaths, nor any signs of systemic toxicity or dermal irritation.
All animals showed expected gains in bodyweight over the study period. No
abnormalities were noted at necropsy. The
acute dermal median lethal dose (LD50) of the test material in the rat
was greater than 2000 mg/kg bodyweight.
As the oral/dermal LD50 and inhalation LC50 values were higher than the
limit dose/concentration, classification for acute toxicity is not
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again