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EC number: 202-319-2
CAS number: 94-28-0
Table 1: Individual Disintegrations per Minute and Stimulation Indices
(% v/v) in
acetone/olive oil 4:1
dpm = Disintegrations per
a = Total number of lymph
nodes per animal is 2
b = Stimulation Index of
3.0 or greater indicates a positive result
N/A = Not applicable
* = Significantly
different from control group p<0.05
There were no deaths. No signs of systemic toxicity were noted in the
test or control animals during the test.
Bodyweight changes of the test animals between Day 1 and Day 6 were
comparable to those observed in the corresponding control group animals
over the same period.
The test material was considered to be a non-sensitiser under the
conditions of the test.
a preliminary screening test, three
groups, each of five animals, were treated with 50 µl (25 µl per ear) of
the undiluted test material or the test material as solution in
acetone/olive oil 4:1 at concentrations of 25% or 50% v/v. A further
group of 5 animals was treated with acetone/olive oil 4:1 alone. The
stimulation index expressed as the mean radioactive incorporation for
each treatment group divided by the mean radioactive incorporation of
the vehicle control group was 2.33, 1.94 and 2.97 for the 25, 50 and
100% solutions. All
test groups were therefore negative for sensitization.
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