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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: case study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Mixture of compounds, number of exposed subjects in each work group is very small. Health effects reported cannot clearly be attributed to exposure to BMA vapours.

Data source

Reference
Reference Type:
publication
Title:
Pulmonary Abnormalities and Serum Immunoglobulins in Facsimile Machine Repair Technicians|Exposed to Butyl methacrylate Fume.
Author:
Raymond LW
Year:
1996
Bibliographic source:
Chest 109: 1010 - 1018

Materials and methods

Type of study / information:
Type of experience: Human
Endpoint addressed:
respiratory sensitisation
Principles of method if other than guideline:
The study involves standard clinical and respiratory function tests as well as a chemical analysis fo the fumes
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
The emissions generated by the fax process studied were largely composed of deeply respirable BMA (isomer not specified, but more likely n-BMA) and other polymer decomposition products including C-4 fume and vapour phases, as well as some C-2 and C-3 compounds.

Results and discussion

Results:
Exposure to polymer decomposition fumes also containing low levels of Butyl methacrylate (0.6 mg/m3 in air) released from coated fax paper was reported to be associated with respiratory symptoms during 1 to 2 years in seven fax machine repair technicians in New York.
Only few isolated symptoms in another group of workers in a larger room with fume levels from 0.14 to 0.40 mg/m³ in air.

Applicant's summary and conclusion

Conclusions:
In a group of seven fax machine repair technicians in New York a slight increase in respiratory symptoms and an increase in serum IgE was observed. The autors associated this with the exposure to fumes generated during machine operation. According to their results, the fumes (0.6 mg/m3 in air) consisted primarily of Butyl methacrylate (released from a BMA-containing polymer which coated the fax paper), but also other pyrolysis products.
Executive summary:

In a group of seven fax machine repair technicians ina slight increase in respiratory symptoms and an increase in serum IgE was observed. The autors associated this with the exposure to fumes generated during machine operation. According to their results, the fumes (0.6 mg/m3 in air) consisted primarily of Butyl methacrylate (released from a BMA-containing polymer which coated the fax paper), but also other pyrolysis products.