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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Although only a short communication, a dermatological standard method has been reported

Data source

Reference
Reference Type:
publication
Title:
Butyl methacrylate monomer and ethyl methacrylate - frequency of reaction
Author:
Maibach H, Hjorth N, Fregert S et al.
Year:
1978
Bibliographic source:
Contact Derm, 4: 60

Materials and methods

Type of sensitisation studied:
skin
Study type:
survey
Principles of method if other than guideline:
542 dermatitis patients were tested with 1% n-butyl methacrylate in petrolatum
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Type of population:
other: patients with dermatitis
Subjects:
- Number of subjects exposed: 542
- Sex: no data
- Age: no data
- Race: no data
- Demographic information: no data
Clinical history:
- History of allergy or casuistics for study subject or populations: contact dermatitis
Route of administration:
dermal
Details on study design:
TYPE OF TEST(S) USED: patch test (epicutaneous test)

ADMINISTRATION
- Type of application: A1-Test or Finn chamber
- Description of patch:
- Vehicle / solvent: petrolatum
- Concentrations: 1%
- Volume applied: no data
- Testing/scoring schedule: 48 h and96 h
- Removal of test substance: no data

EXAMINATIONS
- Grading/Scoring system: ICDRG scale
- Statistical analysis: no data

Results and discussion

Results of examinations:
1/542 patients reacted to butyl methacrylate (1% in petroleum)

Applicant's summary and conclusion

Conclusions:
1/542 patients reacted to butyl methacrylate (1% in petroleum). Past history of dermatitis and use of acrylic paints was proposed as being of relevance.
Executive summary:

5421 patients with dermatitis were patch-tested for allergic reactions. 1 patient reacted to butyl methacrylate (1% in petroleum). Past history of dermatitis and use of acrylic paints was proposed as being of relevance.