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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
cytotoxicity
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published data

Data source

Reference
Reference Type:
publication
Title:
Cytotoxicity of methyl|methacrylate (MMA) and related compounds and their interaction with dipalmitoylphosphatidylcholine (DPPC)|liposomes as a model for biomembranes.
Author:
Fujisawa S, Atsumi T, Kadoma Y
Year:
2000
Bibliographic source:
Oral Diseases 6/4: 215 - 221

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: not known
Principles of method if other than guideline:
Study to clarify the potential mechanism of action of Methyl methacrylate (MMA) and related compounds to membranes of  living cells, compared with their interaction with dipalmitoylphosphatidylcholine (DPPC) liposomes as a model for biological membranes.
GLP compliance:
not specified
Type of method:
in vitro

Test material

Reference
Name:
Unnamed
Type:
Constituent

Administration / exposure

Details on study design:
For (meth) acrylates, MMA, ethyl acrylate (EA), n-butyl acrylate (BA) and n-butyl methacrylate (BMA) and for living cells, primary human gingival fibroblast (HGF), human submandibular gland adenocarcinoma cell line (HSG) and human erythrocytes were used. The physico-chemical changes in DPPC liposomes induced by (meth) acrylates were studied using differential scanning calorimetry (DSC) and nuclear magnetic resonance spectroscopy (NMR).

Results and discussion

Details on results:
Cytotoxicity decreased as follows: Butyl acrylat > n-Butyl methacrylate > Ethyl acrylate > Methyl methacrylate

Applicant's summary and conclusion

Conclusions:
Using a valid experimental method, n-Butylmethacrylate exhibited large cytotoxicity and high Dipalmitoylphosphatidylcholine (DPPC)-interaction due to their lipophilicity compared to Ethyl acrylate or Methyl methacrylate.
Executive summary:

Using a valid experimental method, n-Butylmethacrylate exhibited large cytotoxicity and high Dipalmitoylphosphatidylcholine (DPPC)-interaction due to their lipophilicity compared to Ethyl acrylate or Methyl methacrylate.