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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data are given.

Data source

Reference
Reference Type:
publication
Title:
Embryonic-fetal toxicity and teratogenic effects of a group of ethacrylate esters in rats.
Author:
Singh AR, Lawrence WH, Autian J
Year:
1972
Bibliographic source:
J. Dental. Res. 519(6): 1632-1638

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
n-Butyl methacrylate, purity not specified

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
female
Details on test animals and environmental conditions:
The test animals were 175 to 225 gm, adult, virgin female rats. Male rats  of the same strain and age were used as the "stud pool".

Administration / exposure

Route of administration:
intraperitoneal
Details on study design:
 Acute toxicity  was determined by administration of graded doses of these specific  samples by intraperitoneal injection in rats and observation of the rats  for 7 days for mortality.
Statistics:
Acute LD50-values and 95 % confidence limits were calculated by Cornfield  and Mantel's modification of Karber's method or by the method of Weil.

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
2 059 mg/kg bw

Any other information on results incl. tables

Original value: 2.3039 ml/kg (1.8811 - 2.8217 ml/kg 95 % confidence limit)
Density: 0.8948 g/cm3

Applicant's summary and conclusion