Registration Dossier
Registration Dossier
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EC number: 264-150-0 | CAS number: 63449-39-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1964
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Paraffin waxes and Hydrocarbon waxes, chloro
- EC Number:
- 264-150-0
- EC Name:
- Paraffin waxes and Hydrocarbon waxes, chloro
- Cas Number:
- 63449-39-8
- Molecular formula:
- C18H33Cl5 C18H30Cl8 C20H36Cl6 C20H33Cl9 C25H45Cl7 C25H42Cl10 C25H29C23 C30H53Cl9 C30H49Cl13 C30H35Cl27
- IUPAC Name:
- Paraffin waxes and Hydrocarbon waxes (C18 and longer), chloro
- Details on test material:
- C22-30; 70% Cl (solid); stabilized with 1.0% epoxidised vegetable oil, 0.05% hydrated oxalic acid and 0.05% ethylene glycol. Cereclor 70 (stabilized).
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 50% suspension in dispersing agent
- Details on exposure:
- Three female rats were given 5.0 g/kg bw of the test material i.p. and observed for one week.
- Doses:
- 5.0 g/kg/bw
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
Any other information on results incl. tables
All animals showed piloerection, slight urinary incontinence, muscular weakness and slight forelimb tremor. The effects abated but, after one week, they all remained weak and were unsteady. No pathological lesions were noted but the substance seemed to precipitate on the viscera and mesentery. A moderate ascites was present.
Applicant's summary and conclusion
- Conclusions:
- All animals showed piloerection, slight urinary incontinence, muscular weakness and slight forelimb tremor. The effects abated but, after one week, they all remained weak and were unsteady. No pathological lesions were noted but the substance seemed to precipitate on the viscera and mesentery. A moderate ascites was present.
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