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EC number: 246-690-9
CAS number: 25167-70-8
Renal lesions associated with 2,4,4 -trimethylpentene administration were induced by alpha-2u-globulin and are therefore not relevant for human risk assessment.
In an oral developmental / reproductive
toxicity study on 2,4,4 -trimethylpentene (>95% pure) an increased
incidence of hyaline droplets in the proximal tubules of the kidney in
male, but not female rats was reported (HLS, 1997c). An investigative
study used kidney sections from the original study to determine if the
hyaline droplets observed in the original study were composed of
alpha-2u-globulin using mouse anti-alpha-2u-globulin monoclonal
antibodies (Swenberg and Schoonhoven, 2004 ).
These investigative studies identified that
2,4,4 -trimethylpentene, like structural analogues, produced
alpha-2u-globulin nephropathy in male rats. Alpha-2u-globulin
nephropathy is a male rat-specific toxicity and is not relevant to human
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