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EC number: 246-690-9
CAS number: 25167-70-8
2,4,4-trimethylpe The results of the Biowin and BioHCwin for 2,4,4-trimenthylpentene indicate that it is expected to biodegrade rapidly, with a half-life of 6.7589 days.
use of a QSAR to predict the biodegradability of the substance is an
appropriate technique as these substances clearly fall within the
applicability domain of the model, with all substructures included in
the model. The results indicate that the substance is expected to
biodegrade rapidly, with a half life of 6.7589 days.
use of QSAR estimates to predict the biodegradability of hydrocarbons
because they are included in the training sets of the BIOWIN and BioHC
databases were created using experimental biodegradation data for
compounds found in crude oil and its products, with biodegradation
references obtained for each of these compounds, mainly from the BIOLOG
and DATALOG files of EFDB, TOXLINE and American Chemical Society
Chemical Abstracts as well as literature searches. For the BioHC model,
a single recommended biodegradation half-life was chosen for use in the
regression analysis from the primary biodegradation data that were
compiled for each hydrocarbon structure.
The supporting studies by Hydrotox (2004)
and Wildlife International (2006) are GLP compliant and follow standard
guidelines. They both support the characterisation of 2,4,4
-trimethylpentene as not readily biodegradable. In the EU RAR (2008), it
is concluded that, based on the available information a sound assessment
of biodegradation is not possible, so as a worst-case
2,4,4-trimethylpentene has to be assessed as not biodegradable. The data
are supported by the results from the QSAR estimations using the
BIOWINand BioHC models.
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