Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-918-9
CAS number: 101-14-4
Data from a combined repeated dose and reproductive/developmental toxicity screening test of 4,4'-methylenebis (2-chlorobenzenamine) by oral administration in rats performed according to GLP principles and OECD guidelines were available to cover this endpoint.
Sprague-Dawley rats were treated with 0,
0.4, 2, 10, and 50 mg/kg 4,4'-methylene bis (2-chloro-aniline) once
daily during 42 days (males) or up to 4 days after delivery (females).
4,4'-methylene bis (2-chloro-aniline) had toxic effects on the spleen,
liver and kidneys following repeated administration in rats. Overall, a
NOEL of 2 mg/kg was reported for 4,4'-methylene bis (2-chloro-aniline).
Based on the above mentioned results, the
substance does not need to be classified according to the
Substance Directive 67/548/EC andCLP
Regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Deze website maakt gebruik van cookies om het surfen zo aangenaam mogelijk te maken.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again