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EC number: 200-836-8 | CAS number: 75-07-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
As actaldehyde is produced and used as an intermediate under industrial strictly controlled conditions only an occupational exposure limit is necessary. For Germany the MAK commission derived the offical occupational exposurelimit:
MAK-value= 50 ppm (91 mg/m3) (TRGS 900 2010, DFG 2008, AGS 2010).
Justification: Acetaldehyde has shown clastogenic, aneugenic and weak mutagenic activity. The observed nasal tumors coincided with cytotoxic effects at the nasal mucosea. As the irritating effects seem to play a major role for tumor formation, the occupational exposure limit (50 mL/m3) was primarily based by the "MAK Kommission" on the assumed no effect level for human sensory irritation. It was calculated from the NOAEC for respiratory tract irritation in the rat in a 4 week study (150 ml /m3) devided by three. The factor of three was evaluated from the database on formaldehyde that has a comparable mode of action regarding the irritation properties. Additionally, the "MAK Kommision" concluded that compliance with the occupational exposure limit would guarantee that the thereoff calculated liftime incremental charge with acetaldehyde (1.0 µmol / L blood) does not exeed the endogenous variation limit of acetaldehyde (endogenous level = 2,2 +/- 1.1 µmol/L; Fukunaga et al 1993). Based on this calculation and the fact that in animals no systemic tumors were observed at concentrations that caused local tumors it was not expected that exposure to acetaldehyde below 50 mL/m3 has a significant contribution to the lifetime cancer risk. Nevertheless it could not be completely excluded that genotoxic effects (DNA crosslinks and adducts) occur at these concentration locally in the nose. Regarding developmental toxicity the following calculation was made. Based on a NOAEL of 400 mg/kg bw per day from the most reliable study a NOAEC of 2800 mg/m3 (=1538 mL/m3) and 720 mg/m3 can be calculated according to the "MAK Kommision" (DFG 2008) and the "Ausschuß für Gefahrstoffe" (AGS 2010). As the margin of safety with regard to the MAK value is then around 30 and 8, respectively, both institutions concluded that the risk for developmental toxicity effects is adequatly controled by the MAK value.
Sources:
TRGS 900, Technische Regeln Gefahrstoffe, Bundesministerium für Arbeit und Soziales 2010, http://www.baua.de/cae/servlet/contentblob/666762/publicationFile/55588/TRGS-900.pdf
AGS, Ausschuß für Gefahrstoffe 2010, http://www.baua.de/cae/servlet/contentblob/879348/publicationFile/55468/900-acetaldehyd.pdf
DFG, Deutsche Forschungsgemeinschaft - MAK Kommision 2008
Fukunaga T, Sillanaukee P, Eriksson CJP (1993) Problems involved in the determination of endogenous acetaldehyde in human blood. Alcohol alcohol 28: 535-541
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
not relevant
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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