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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: hazard assessment report
Adequacy of study:
supporting study
Study period:
-1995
Reliability:
other: reliable hazard assessment
Rationale for reliability incl. deficiencies:
other: International hazard assessment

Data source

Reference
Reference Type:
other: hazard assessment
Title:
Acetaldehyde
Author:
WHO- International Programm on Chemical Safety
Year:
1995
Bibliographic source:
Environmental Health criteria 167

Materials and methods

Principles of method if other than guideline:
no data available
GLP compliance:
not specified
Test type:
other: different methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: rats, mice and dogs

Results and discussion

Any other information on results incl. tables

Table 1. LD50 values for Acetaldehyde after oral exposure

Rat

oral

1930 mg/kg bodyweight

Smyth et al. (1951)

Rat

oral

660 mg/kg bodyweight

Sprince et al. (1974)

Mouse

oral

1230 mg/kg bodyweight

US NRC (1977)

Dog

oral

> 600 mg/kg bodyweight

Booze&Oehme(1986)

 

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Oral LD50s for acetaldehyde in rats and mice ranged from 660 to 1930 mg/kg body weight.
Executive summary:

The lowest observed LD50 in the rat was 660 mg/kg bw. According to this value Acetaldehyde is harmful if swallowed.