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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1946
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Further studies on sensory response to certain industrial solvent vapors
Author:
Leslie Silverman
Year:
1946
Bibliographic source:
Journal of industrial hygiene and toxicology, 28, p. 262

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
eye irritation
Principles of method if other than guideline:
eye irritation by vapor exposure
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no details available

Method

Type of population:
occupational
Subjects:
12 subjects of both sexes
Ethical approval:
not specified
Route of exposure:
other: gas
Reason of exposure:
intentional
Exposure assessment:
not specified
Details on exposure:
Exposure to 25, 50 and 200 ppm for 15 min
Examinations:
eyes, sensory organs
Medical treatment:
-

Results and discussion

Clinical signs:
reddened eyelids and bloodshot eyes
Results of examinations:
-
Effectivity of medical treatment:
-
Outcome of incidence:
-

Applicant's summary and conclusion

Conclusions:
Acetaldehyde is irritating to the eyes of human.
Executive summary:

Acetaldehyde was investigated for sensory effects on humans. At 200 ppm bloodshot eyes and reddened eyelids were reported. It can be assumed that direct contact of acetaldehyde with the human eye will have similar or more severe effects.