Registration Dossier
Registration Dossier
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EC number: 203-809-9 | CAS number: 110-86-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Pyridine was found in a reputable industry laboratory to be non-sensitising in guinea pigs (Anonymous, Eastman Kodak Company, 1978, and this is underscored in a reliable toxicology text, Patty's Industrial Hygiene and Toxicology, 1991. Pyridine was included in the validation data set for the ICCVAM Local Lymph Node Assay, and was found to be a weak sensitiser. The authors of the ICCVAM study noted that this positive result was unexpected, since it was considered not to be a sensitising substance. In a human case series after an accidental laboratory exposure with a mixture of chemicals (including pyridine), pyridine was found to be sensitising in dermatology patients (Sasseville, et al., 1996). There is a narrow range of cross-reactivity of sensitisers among pyridine compounds (Sasseville, et al., 1998). In accordance with Regulation (EC) No. 1272/2008, Annex VI, Index # 613-002-00-7, this substance is not classified (harmonized) as a dermal sensitiser.
Migrated from Short description of key information:
This substance is judged by a weight of evidence to be non-sensitising to the skin, in accordance with harmonized classification of Regulation (EC) No. 1272/2008.
Justification for selection of skin sensitisation endpoint:
experimental data
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
- Migrated from Short description of key information:
There is no data on respiratory sensitisation.
Justification for classification or non-classification
Conflicting data exist for the sensitisation potential of pyridine. It is not sensitising in the guinea pig, while local lymph node data in the mouse suggests that it is a weak sensitiser. In the absence of firm data to the contrary, pyridine retains its harmonized classification of pyridine as a non-sensitiser (Regulation (EC) No. 1272/2008, Annex VI, Index # 613-002-00-7).
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