Registration Dossier
Registration Dossier
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EC number: 203-809-9 | CAS number: 110-86-1
Endpoint summary
Administrative data
Description of key information
This substance has relatively low acute toxicity via the oral, inhalation and dermal routes (Category 4).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 800 mg/kg bw
- Quality of whole database:
- adequate
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 15 852 mg/m³ air
- Quality of whole database:
- adequate
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 100 mg/kg bw
- Quality of whole database:
- adequate
Additional information
The acute oral LD50 is greater than 800 and less than 1600 mg/kg bw, and a value of 800 is selected. Rather than adopt the ATE (Acute toxicity point estimate) assignment (500 mg/kg bw) according to Regulation EC No. 1272/2008, a value which is out of the range of experimental values (800 -1600 mg/kg bw), the lower range of 800 mg/kg bw is chosen for the point estimate.
The acute dermal toxicity is greater than 1000 and less than 2000 mg/kg bw in rabbits, and a value of 1100 is selected as an ATE. The acute inhalation LC50 is greater than 4900 but less than 6000 ppm. The value selected is 4900 ppm.Rather than adopt the ATE assignment (4500 ppm) which is out of the range of experimental values (4900 - 6000 ppm), the lower range of 4900 ppm is chosen for the point estimate. This is equivalent to 15852 mg/m3.
Justification for selection of acute toxicity – oral endpoint
experimental value
Justification for selection of acute toxicity – inhalation endpoint
experimental value
Justification for selection of acute toxicity – dermal endpoint
experimental value
Justification for classification or non-classification
Pyridine is classified as Category 4 for acute oral, dermal and inhalation, according to Regulation EC No. 1272/2008. This conclusion is based on the following:
The acute oral LD50 of 800 is between 300 and 2000 mg/kg for Category 4.
The acute dermal LD50 of 1100 is between 1000 and 2000 mg/kg for Category 4.
The acute inhalation LC50 of 15852 is between 2500 and 20000 mg/m3 for Category 4.
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