Registration Dossier
Registration Dossier
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EC number: 203-809-9 | CAS number: 110-86-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Pyridine and its methyl derivatives are rapidly absorbed and distributed to the body water component. They are metabolized in the liver and eliminated in the urine. There is a low risk of bioaccumulation
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
Pyridine and its methyl derivatives are absorbed during inhalation, oral and dermal exposures. They are distributed into the body water compartment as evidenced by the finding of the highest levels in the kidney and being eliminated primarily in the urine. Pyridine and its derivatives are metabolised by CYP enzymes in the liver, with primary metabolites being pyridine-N-oxide, 2-pyridone, 4-pyridone, 3-hydroxypyridine, and N-methyl pyridinium ion. These substances have a low risk of bioaccumulating in body fat or milk.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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