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EC number: 221-975-0
CAS number: 3302-10-1
3,5,5 -trimethylhexanoic acid did not induce skin sensitisation in a
guinea-pig maximisation test. No cases of skin sensitisation have been
observed in two large companies producing 3,5,5 -trimethylhexanoic acid
and no cases are reported in the literature.
There is no information available on respiratory sensitising effects of
3,5,5 -trimethylhexanoic acid.
Result: negative (no further details provided)
The test substance was not sensitising in a guinea pig maximisation test
(no details reported) (Cronin, 1994).
In vitro data:
Skin sensitisation in vitro has not been investigated as there is
sufficient information available for the submission substance.
3,5,5-trimethylhexanoic acid did not induce skin sensitisation in a
guinea pig maximisation test. This assay has been performed according to
a generally accepted methodology. No indication for skin sensitisation
was obtained. This negative result is supported by the findings of the
OECD Toolbox profiler which did not indicate an alert for skin
Human experience (chapter 7.10.4):
No cases of sensitisation in workers were observed by the occupational
medicine department of Hoechst AG and BASF AG, two major producers of 3,
5, 5-trimethylhexanoic acid, during many years of production and further
processing of the test substance (BASF 1997; Hoechst 1997; cited in BG
Further,the Information Network of Departments of Dermatology for
the surveillance and scientific evaluation of contact allergies in
Germany, stated that there are no data on the sensitizing potential of
isononanoic acid, and deemed it unlikely that the chemical has any
allergenic potential (IVDK 1997; cited in BG Chemie, 2005).
Overall, 3, 5, 5-trimethylhexanoic acid is not likely to
have sensitizing properties.
Based on the negative findings in a guinea-pig maximisation test and the
experience with 3,5,5 -trimethylhexanoic acid from the workplace it is
concluded that the submission substance 3,5,5-trimethylhexanoic acid
does not cause skin sensitisation and has not to be classified as skin
sensitiser according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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