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EC number: 221-975-0
CAS number: 3302-10-1
Skin irritation: The undiluted test substance was reported to be irritating to skin in the key study with rabbits, an effect also seen in further reliable animal studies. Corrosive effects were not evident.Eye irritation: The undiluted test substance was slightly to moderately irritating to the eye in reliable rabbit studies, but effects were still present at the end of the observation time.No human data are available with respect to skin or eye irritation.Respiratory irritation: The RD50 (concentration producing a 50% decrease in respiratory frequency) in mice was 420 mg/m3.
Er: erythema score, Ed: edema score
Rabbits were exposed for 4 h under occlusive conditions to 0.5 mL of the
test item in a skin irritation test according to OECD TG 404 (Hüls AG,
1986). At the end of the exposure period and at the 24 -48 -72 hour
reading there was erythema as well as edema formation, accompanied by
yellow-brown discolouration and hardening of the application sites. Mean
24 -48 -73 h erythema and edema scores were 3 and 3, respectively.
Eschars persisted until day 14, and began to peel off from day 10 on.
Effects on eyes have been assessed in a test according to OECD TG 405.
The application of undiluted test substance to the eyes of rabbits
produced an eye irritation to be considered as severe (effects still
present at the end of the observation time; overall irritation score:
41.48/110, cornea score:1.78/4, iris score: 1/2, conjunctivae score:
3.0/3, chemosis score: 1.0/4) (Hüls AG, 1986).
Skin irritation: The key study reports an erythema score of 3.0 and an
edema score of 3.0 (Hüls, 1986, RL1). A further reliable study documents
lower scores of 1.0 and 0, respectively, with skin effects like scaly,
dry, and rough skin, which were still present at the end of the 14 -day
observation period (Hoechst, 1985, RL1). Both studies were performed
according to guidelines EU B4 and OECD 404. A secondary report of an
unavailable study reports slight skin irritation with scores < 2.0
(Exxon, undated). An additional study with 24 hour exposure time
revealed skin irritating effects (erythema score 2.9; edema score 1.9,
not reversible within 8 days). One of six treated animals showed a
slight, superficial necrosis which did not extent to deeper skin layers,
i.e. is not relevant with respect to classification as skin corrosive.
Eye irritation: The key study reports a moderate irritating effect to
the eye. Lesions were still present at the end of the observation time
therefore the eye irritation has to be considered as severe (Hüls, 1986,
RL1: cornea score: 1.78; iris score: 1.0; conjunctiva reddening score:
3.0; chemosis score: 1.0). A similar result (slight but irreversible eye
effects) was also observed in a further study by BASF AG (1980). A
further reliable study documents lower scores (Hoechst, 1985, RL1: 0;
0.8; 2.1 and 1.7, respectively). Studies of restricted reliability
(Hoechst, 1970; Exxon undated) report moderate and slight irritating
Respiratory irritation: The RD50 (concentration producing a 50% decrease
in respiratory frequency) in mice was 420 mg/m3. According to the
authors, the effect was mainly based on pulmonary irritation
(Detwiler-Okabayashi and Schaper, 1996). The study per se is reliable,
but the result is of unclear relevance with respect to the
classification of endpoint respiratory irritation, as no supportive data
(e.g. histological examinations) are available.
Based on the results of the key study for skin irritation a
classification as skin irritant (Category 2) is recommended according to
Regulation (EC) No 1272/2008.
Based on the results of the key study for eye irritation, a
classification for irreversible effects on the eye (Category 1) is
recommended according to Regulation (EC) No 1272/2008.
Reliable and relevant data for the endpoint respiratory irritation are
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