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Description of key information

There are no data available on bioaccumulation potential, oral, dermal or inhalation absorption rate.

Key value for chemical safety assessment

Additional information

3,5,5-trimethylhexanoic acid is expected to be rapidly absorbed after oral uptake. To all appearances it does not undergo ß-oxidation due to an un-even position of the methyl substitution. The metabolism is suspected to accur via chain hydroxylation and subsequent formation of ketoacid or dicarbonic acids, which are excreted into bile or urine or cleaved in the gut and undergo entero-hepatic circulation.

No noteworthy formation of 3,5,5-trimethylhexanoic acid is expected from the corresponding alcohol, because the latter is expected to be a poor substrate for alcoholdehydrogenase. Therefore, data from this substance are not relevant for the risk assessment of 3,5,5 -trimethylhexanoic acid (Semino, 1998).

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