Registration Dossier
Registration Dossier
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EC number: 451-540-2 | CAS number: -
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- Analytical monitoring on initial solution and for each sampling time.
- Preliminary test: 0h, 2.4h, and 120h (pH4.0 and 7.0-50°C) and 0h and 2.4h (pH 9.0-50°C)
- Test 1 (pH 7.0-50°C): 0, 3, 4.5, 5.5, 6.5, 7.5 and 9h
- Test 2 (pH 7.0): 0, 2 and 4.25h (61°C) ; 0, 1 and 2h (72°C) - Buffers:
- 3 buffer solutions: pH 4.0, pH 7.0 and pH 9.0; pH checked before used
Results and discussion
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- 8.71 h
- pH:
- 7
- Temp.:
- 61
- DT50:
- 2.84
- pH:
- 7
- Temp.:
- 72 °C
- DT50:
- 1.1 h
- pH:
- 7
- Temp.:
- 25
- DT50:
- 131 h
- Remarks on result:
- other: extrapolation
Any other information on results incl. tables
pH |
T ˚C |
t1/2 |
4.0 |
25 |
> 1 year |
7.0 |
25 |
131 h (extrapolation) |
9.0 |
unstable |
|
Applicant's summary and conclusion
- Conclusions:
- - Thiofestermet hydrolytically stable at pH 4.0 (T1/2 > 1year at 25°C)
- Thiofestermet hydrolytically unstable at pH 7.0 (T1/2 =131h at 25°C)
- Thiofestermet hydrolytically unstable at pH 9.0
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