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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Screening test with basic information and result reporting. Appears valid.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report Date:
1972

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The observation period was 7 days, and animals per dose was not according to guideline.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No data available.

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
- Weight at study initiation: 215-260g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: undiluted
Details on oral exposure:
No detail available.
Doses:
5010 mg/kg, 7940 mg/kg, 12600 mg/kg, 15800mg/kg
No. of animals per sex per dose:
5010mg/kg; 1F, 7940mg/kg; 1F, 12600mg/kg; 1F, 15800mg/kg; 3M, 2F.
Control animals:
not specified
Details on study design:
Observations were made for toxic signs and the viscera of the test animals were examined macroscopically. Observation period 7 days.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 15 800 mg/kg bw
Mortality:
No animals died.
Clinical signs:
Toxic signs included reduced appetite and activity and lethargy lasting two to three days.
Gross pathology:
Surviving animals were sacrificed seven days after dosing. The viscera appeared normal by macroscopic examination.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
The rat oral LD50 for undecyl alcohol was >15800 mg/kg. The study was not conducted according to GLP and the observation period was 7 days.