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EC number: 932-235-8
CAS number: -
Cyclophosphamide (200 mg/kg)
White Spirit (0.01mL i.p.)
White Spirit (0.05mL i.p.)
White Spirit (0.1mL i.p.)
White Spirit (50g/m3 by inhalation)
The ability of white spirit to produce chromosomal aberrations in vivo
in mammalian somatic cells was studied by examining eight-week-old
BALB/c male and female mice for the presence of micronuclei in the
polychromatic erythrocytes from bone marrow.
The animals were sacrified 30 h after i.p. injection of 0.l, 0.05 or
0.01 ml of white spirit. In addition, male animals were allowed to
inhale 50 g/m3 of white spirit, during 5 periods of 5 min spaced by
intervals of 5min. According to Carpenter et al. (1975) 50 g/m3
represents about 50 times the limit of toxicity. Animals given 200 mg
cyclophosphamide per kg b.w. were used as positive controls. When
compared to control animals, it was concluded that white spirits are not
mutagenic or clastogenic.
Carpenter C. P., Kinkead E. R., Geary, Jr. D. L., Sullivan L. J., and
King J. M. Petroleum Hydrocarbon Toxicity Studies.Animal and Human
Response to Vapors of Stoddard Solvent. 1975. Toxicology and Applied
Pharmacology. 32: 282-297.
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