Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 932-235-8
CAS number: -
To evaluate the neurobehavioral effects of hydrocarbon solvents and to
establish a working model for extrapolating animal test data to humans,
studies were conducted, which involved inhalation exposure of rats and
humans to white spirit (WS). The specific objectives of these studies
were to evaluate the behavioral effects of exposure to WS in rats and
humans and to determine relationships between internal levels of
exposure and behavioral effects. In both animals and volunteers, methods
for assessment of similar functional effects were used to enable
interspecies comparisons. A battery of tests including standardized
observational measures, spontaneous motor activity assessments and
learned visual discrimination performance was utilized in rat studies to
evaluate acute central nervous system (CNS) depression. Groups of rats
were exposed to WS at target concentrations of 0, 600, 2400 or 4800
mg/m3, 8 h/day for 3 consecutive days. Blood and brain concentrations of
two WS constituents; 1,2,4-trimethylbenzene (TMB) and n-decane (NDEC),
were used as biomarkers of internal exposure. The NOAEL for acute CNS
effects in rats was determined to be 600 mg/m3. In a volunteer study, 12
healthy male subjects were exposed for 4 hours to either 57 or 570
mg/m(3) WS in two test sessions spaced 7 days apart, and neurobehavioral
effects were measured using a computerized neurobehavioral test battery.
Blood samples were taken at the end of the exposure period to measure
internal concentrations of TMB and NDEC. Results of the behavioral tests
in rats indicated WS-induced changes particularly in performance and
learned behavior. In humans, some subtle performance deficits were
observed, particularly in attention. The results indicated that the
NOAEL for acute CNS effects in humans was at or near 570 mg/m3. The
behavioral effects were related to concentrations of the WS components
in the central nervous system. These studies demonstrated a qualitative
similarity in response between rats and humans, adding support to the
view that the rodent tests can be used to predict levels of response in
humans and to assist in setting occupational exposure levels for
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Deze website maakt gebruik van cookies om het surfen zo aangenaam mogelijk te maken.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again