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EC number: 218-664-7
CAS number: 2212-81-9
The acute oral toxicity of the test item, 1,3(4)‑bis(tert-butylperoxyisopropyl)benzene
(batch No. 307090713), was evaluated in rats according to OECD
17th December 2001) and Commission
Regulation (EC) (No. 440/2008, B.1tris, 30 May 2008) guidelines.
study was conducted in compliance with the principles of Good Laboratory
The test item was prepared in
0.5% methylcellulose and was administered by oral route (gavage), under
a volume of 10 mL/kg, to groups of three fasted female Sprague-Dawley
rats. The study design
was as follows:
Clinical signs, mortality and body
weight gain were checked for a period of up to 14 days following the
single administration of the test item.
animals were subjected to necropsy.
Neither mortality nor clinical signs
were observed during the study.
When compared to CIT historical control data, a lower body weigh
gain was noted in 2/6 animals (6 and 8 g vs. 17 ± 8 g in
historical data base) between day 8 and day 15.
necropsy, no apparent abnormalities were observed in any animals. Under
the experimental conditions of this study, the oral LD0of the
test item 1,3(4)‑bis(tert‑butylperoxyisopropyl)benzene (batch No.
307090713) was higher than 2000 mg/kg in rats.
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