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EC number: 218-664-7
CAS number: 2212-81-9
Based on log Kow and on water solubility, it
is assumed that the read-across substance, CAS 25155 -25 -3
is not completely absorbed by
inhalation exposure and that inhalation absorption factor doesn’t exceed
oral absorption factor.
Dermal absorption is supposed very low for
several reasons: i) The substance is dry and practically non soluble in
water (<0.62 mg/l, if water solubility is < 1 mg/l, dermal uptake is
likely to be low); the experimental log Kow is > 5.5 and the calculated
log Kow is 7.3; therefore very few of the substance goes from the
stratum corneum to the epidermidis. ii) The molecular weight is 338.5
g/mol, so not really in favour of dermal absorption (below 100: in
favour of dermal absorption, above 500, not in favour of absorption).
iii) the substance is not a skin irritant, therefore no increase of skin
absorption is expected. Therefore, dermal absorption can be reasonably
estimated to be lower than 10%. No data is available on absorption by
oral route, which is therefore assumed to be 100%.
There are no consumer uses for this
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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