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EC number: 218-664-7
CAS number: 2212-81-9
The in vitro rate
of metabolism was determined for the read across source [1,3(or 1,4)-
Phenylenebis(1-methylethylidene)] bis[tert-butyl] peroxide using the in
trout liver S9 assay (OECD Test Guideline 319B).
This organic peroxide
metabolized rapidly under biologically active conditions with a
metabolic half- life of 67 minutes or 1.13 hours. This data was used to
extrapolate in vivo rate constants of metabolism or kMETof
0.184 day-1or 0.475 day-1using hepatic portal
blood flow or hepatic portal and arterial blood flow, respectively. The
use of these kMET values
in conjunction with the Gobas model dropped the calculated BCF from
45,294 kg day-1(assuming no metabolism) to 536 or 209 kg day-1.
The impact of metabolism on the read across source [1,3(or 1,4)-
Phenylenebis(1-methylethylidene)] bis[tert-butyl] peroxide drops the BCF
to less than the action level of 2000 (Reach Criteria) and should not be
considered to have significant bioaccumulation potential.
However, following the
Echa decision number SEV-D-2114369067-43-01/F, a bioaccumulation in fish
study according to the OECD 305 using the aqueous exposure was performed
under flow-through conditions on the read across source. The results are
based on the time-weighted average as requested in the Echa decision.
Based on this, the steady-state BCFss is equal to 1083 L/Kg and the
steady-state BCFss normalised to a fish lipid content of 5% is equal to
1635 L/Kg.The lipid noramlised and growth corrected kinetic BCFkLg value
is equal to 1820 L/kg.
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