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Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1999
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Principles of method if other than guideline:
48 h screening test with 20 daphnids per dose level.
GLP compliance:
not specified
Specific details on test material used for the study:
Test material: FAT 93450/A
Analytical monitoring:
no
Vehicle:
not specified
Test organisms (species):
Daphnia magna
Details on test organisms:
no data
Test type:
not specified
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Hardness:
not specified
Test temperature:
Start: 19 °C; end: 21 °C
pH:
Start: 7.9; end: 7.9
Dissolved oxygen:
Start: 98 %; end: 97 %
Nominal and measured concentrations:
Nominal: 100 mg/L
Reference substance (positive control):
no
Duration:
48 h
Dose descriptor:
EC0
Effect conc.:
100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
48 h
Dose descriptor:
EC100
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Validity criteria fulfilled:
yes
Conclusions:
The EC0 for Daphnia magna was determined to be 100 mg/L (i.e. ca. 96 mg a.i./L). The EC50 and EC100 were both >100 mg/L (i.e. ca. >96 mg a.i./L).
Executive summary:

A study was conducted to evaluate the acute toxicity of the test substance (at ca. 96 % purity) to Daphnia magna. Groups of 20 daphnids were exposed at 0, 0.39, 1.56, 6.3, 25 or 100 mg/L for 48 h.

No significant effects were seen on mobility throughout the study. Sedimentation of the test substance was observed as of 6.3 mg/L. The EC0 was determined to be 100 mg/L (i.e. ca. 96 mg a.i./L). The EC50 and EC100 were both >100 mg/L (i.e. ca. >96 mg a.i./L).

Description of key information

A study was conducted to evaluate the acute toxicity of the test substance (at ca. 96 % purity) to Daphnia magna. Groups of 20 daphnids were exposed at 0, 0.39, 1.56, 6.3, 25 or 100 mg/L for 48 h. No significant effects were seen on mobility throughout the study. Sedimentation of the test substance was observed as of 6.3 mg/L. The EC0 was determined to be 100 mg/L (i.e. ca. 96 mg a.i./L). The EC50 and EC100 were both > 100 mg/L (i.e. ca. >96 mg a.i./L).

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
96 mg/L

Additional information