Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
low hazard (no threshold derived)

Additional information - workers

The chemical intermediate "Dioxy Cuite Brute 58%" "DCB" is a mixture of molecules and mainly composed of 4,4'-sulfonyldiphenol (BPS) and other sulfonated phenol sodium salts (sulphonated phenol and phenol: see the detailed composition in section 1.2).

DCB is soluble in water and in a little amount of solvent. The salified form increases the solubility of the molecules compared to the acid form. On the other hand, the sulfonic groups tend to bind tightly to proteins and carbohydrates of skin; in addition, part of the mixture has a big molecular dimension (tri-hydroxy).

The molecules that compose the mixture could have different behaviours based on their molecular dimension, the number of the sulphonations and the grade of salifications.

Approximately the 48% of the organic part of the intermediate is composed of BPS CAS 80-09-1.

Approximately the 14% of the organic part of the mixture is the salified form of the phenol sulfonic acid, the benzenesulfonic acid, 4-hydroxy-, sodium salt (1:1), CAS 825-90-1, that in its acid form is a very acidic substance.

In this case, a category approach based on the salified sulfonic acids (hydrotropes) can be taken into account for the hazard evaluation of the whole intermediate mixture DCB 58%.

The specific cation is not expected to have an appreciable effect on fate, ecotoxicity or mammalian toxicity and therefore, the dataset for the entire hydrotropes category can be applied broadly.

The 2,4'-sulfonyldiphenol CAS 5397-34-2 is present at 6 %.

Phenol is present at 1.8 %.

Consideration regarding the conclusion of every endpoint and the classification are reported in every related IUCLID section.

Based on the information available, the intermediate DCB 58% is classified:

H315: Causes skin irritation, Category 2;

H319: Causes eye irritation, Category 2;

H341: Suspected of causing genetic defects, Category 2.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - General Population