Registration Dossier
Registration Dossier
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EC number: 606-870-3 | CAS number: 219715-34-1
Endpoint summary
Administrative data
Description of key information
Skin:
A primary skin irritation test was conducted with rabbits to determine the potential for M-TMP to produce irritation after a single topical application. Under the conditions of this study, the test substance caused very slight to well-defined erythema and very slight edema which cleared by 72 hours.
Eye:
A primary eye irritation test was conducted with rabbits to determine the potential for M-TMP to produce irritation from a single instillation via the ocular route. Under the conditions of this study, the test substance caused conjunctival irritation which cleared by 72 hours.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin:
The key study for skin irritation was conducted in accordance with U.S. EPA Health Effects Test Guidelines, OPPTS 870.2500 (1998). The study was conducted in line with GLP. A reliability rating of 1 according to the criteria of Klimisch, 1997.
Eye:
The key study for eye irritation was conducted in accordance with U.S. EPA Health Effects Test Guidelines, OPPTS 870.2400 (1998). The study was conducted in line with GLP. A reliability rating of 1 according to the criteria of Klimisch, 1997.
Justification for classification or non-classification
Skin:
The key parameter chosen for skin irritation was less than the criteria set out in Directive 67/548/EEC and also Regulation (EC) 1272/2008, therefore classification for skin irritation was not considered to be necessary.
Eye:
The key parameter chosen for eye irritation was less than the criteria set out in Directive 67/548/EEC and also Regulation (EC) 1272/2008, therefore classification for skin irritation was not considered to be necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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