Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 606-870-3 | CAS number: 219715-34-1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
M-TMP sulfinic acid was tested for its acute toxicity to the freshwater daphnid (Daphnia magna), over a 48-hour exposure period. Results were used to calculate median effect concentration (EC50) values. No-observed-effect concentrations (NOEC) were also calculated.
The following guidelines were used to conduct this study:
- USEPA FIFRA, 72-2, EPA 540/9-82-020 (1982)
- USEPA TSCA, 40 CFR 797.1300 (1992)
- OECD, 202 (2004)
- EEC Directive 92/69/EEC, Part C.2 (1992)
The 48-hour daphnid static test was conducted at six treatment levels with nominal concentrations of 3.75, 7.50, 15.0, 30.0, 60.0, and 120 mg/L. A dilution water control was included in the test series. One replicate vessel with ten daphnids was set for each treatment concentration and control for the daphnid test. The daphnids were observed daily for immobility and any changes in behavior or physical appearance.
The acute toxicity values for M-TMP Sulfinic Acid with Daphnia magna were determined based on nominal concentrations. The resulting values are listed below:
- The 48-hour EC50 value was greater than 120 mg/L, the highest nominal concentration tested.
- The 96-hour NOEC was 60.0 mg/L.
Key value for chemical safety assessment
Additional information
EC50 = >120mg/L
The acute toxicity of the test material and water to the Freshwater daphnid (Daphnia magna) was investigated during a study conducted at The Dow Chemivcal Company. The test was performed from May 31 to June 02, 2006 and was conducted according to recognised guidelines and GLP.
This study is presented as the key information as the reliability rating for this study is 2, according to the criteria of Klimisch, 1997, as there was no data reported in this study with regards to analytical monitoring of the test material, this is considered to be a deviation from the guideline and would therefore reduce the reliability.
Based upon the results of the acute daphnia study, the registered substance does not meet the criteria for classification according to 67/548/EEC or EC Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
