Registration Dossier
Registration Dossier
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EC number: 606-870-3 | CAS number: 219715-34-1
Endpoint summary
Administrative data
Description of key information
Oral:
An acute oral toxicity test (Up and Down Procedure) was conducted with rats to determine the potential for M-TMP to produce toxicity from a single dose via the oral route. Under the conditions of this study, the acute oral LD50 of the test substance was estimated to be 1,750 mg/kg of body weight in female rats with an approximate 95% confidence interval of 651.9 mg/kg (lower) to 2,690 mg/kg (upper).
Dermal:
An acute dermal toxicity test was conducted with rats to determine the potential for M-TMP to produce toxicity from a single topical application. Under the conditions of this study, the single dose acute dermal LD50 of the test substance was greater than 5,000 mg/kg of body weight in male and female rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 750 mg/kg bw
Additional information
Oral:
The key study for acute oral toxicity was conducted in accordance with U.S. EPA. Health Effects Test Guidelines, OPPTS 870.1100 (2002). The study was conducted in line with GLP. A reliability rating of 1 according to the criteria of Klimisch, 1997.
Dermal:
Key value = >5000 mg/kg
The key study for acute oral toxicity was conducted in accordance with U.S. EPA. Health Effects Test Guidelines, OPPTS 870.1200 (Acute Dermal Toxicity). The study was conducted in line with GLP. A reliability rating of 1 according to the criteria of Klimisch, 1997.
Justification for classification or non-classification
Oral:
For acute toxicity via the oral route, according to regulation EC No. 1272/2008, the substance should be classified as Category 4 H302 (Harmful if swallowed) with the signal word "Warning". According to directive 67/458/EEC, the substance should be classified as Xn; R22 (Harmful if swallowed).
Dermal:
The key parameter chosen for acute toxicity for the dermal route was greater than the criteria set out in Directive 67/548/EEC and also Regulation (EC) no 1272/2008, therefore classification for acute toxicity was not considered to be necessary.
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