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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Summary report dated 2 January 1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Not a complete report, only results presented.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The dermal LD50 value was derived for amyl cinnamic aldehyde using four treated rabbits. Clinical symptoms and mortalities were monitored.
GLP compliance:
not specified
Test type:
other: modified design based on standard method but limited to group size of four rabbits due to insufficient test material
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
The test material typically contains >94% of the trans (E) isomer and 4-5% of the cis (Z) isomer.

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data provided in report

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
Four rabbits dosed at 2 g/kg bw, no details available for duration of exposure or nature of the bandaging used or any wash-off procedures.
Insufficient test material available to treat a full group and consequently only four animals were tested.
Duration of exposure:
No data
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
4 rabbits
Control animals:
not specified
Details on study design:
No data
Statistics:
No data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
No mortalities were observed
Clinical signs:
No clinical signs observed
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Any other information on results incl. tables

No additional results

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The dermal LD50 for rabbits was greater than 2.0 g/kg. According to Regulation (EC) No. 1272/2008, no classification is warranted, based on the absence of signs of toxicology and mortalities in a group of four rabbits.
Executive summary:

In a study conducted by Moreno (1973), the dermal LD50value was derived for amyl cinnamic aldehyde in a group of four rabbits.

The dermal LD50 for rabbits was greater than 2000 mg/kg bw. According to Regulation (EC) No. 1272/2008, no classification is warranted.