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Several human repeat insult patch tests were conducted to determine the dermal sensitising potential for amyl cinnamaldehyde.  

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No conclusive responses were found to indicate a notable sensitising potential for amyl cinnamic aldehyde in the human population although the human volunteer studies do identify several positive responders but at a low incidence consistent with the predictive response obtained from the LLNA. The predicted response determined from a murine local lymph node assay is that a very low potential for inducing a dermal sensitisation response in the human population is unlikely to exceed the threshold for classification of the substance as even a weak sensitiser. Although alpha-hexyl cinnamic aldehyde has been used as a positive control in sensitisation assays, there is no evidence that the structurally related amyl cinnamaldehyde has the same sensitising potential and cross -sensitivity investigations also indicate one does not induce a response from the other.