Registration Dossier

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
bioaccumulation: aquatic / sediment
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
15/06/2012
Reliability:
2 (reliable with restrictions)
Principles of method if other than guideline:
The bioconcentration factor of amyl cinnamic aldehyde in fish was estimated from the log Kow using BCFBAF v3.01
GLP compliance:
no
Details on sampling:
Not applicable
Details on preparation of test solutions, spiked fish food or sediment:
Not applicable
Test organisms (species):
no data
Hardness:
Estimation by QSAR
Test temperature:
Estimation by QSAR
pH:
Estimation by QSAR
Dissolved oxygen:
Estimation by QSAR
TOC:
Estimation by QSAR
Salinity:
Estimation by QSAR
Details on test conditions:
Estimation by QSAR
Nominal and measured concentrations:
Estimation by QSAR
Details on estimation of bioconcentration:
The bioconcentration facto was estimated using BCFBAF v3.01. The equation used to make the BCF estimate was:

log BCF= 0.6598 log Kow - 0.333 + correction

In this case the measured log Kow was 4.7 (Rudio, 1994) and no correction factor was applicable.
Type:
BCF
Value:
586.2 L/kg
Basis:
whole body w.w.
Remarks on result:
other: QSAR estimate
Details on kinetic parameters:
Not applicable
Metabolites:
Not applicable
Results with reference substance (positive control):
Not applicable
Details on results:
The estimated log BCF was 2.768 (BCF= 586.2 L/kg wet-wt)

No further information

Conclusions:
Based on a QSAR carried out using a measured log Kow, the log BCF of amyl cinnamic aldehyde in fish was estimated to be 2.768 (BCF= 586.2 Lkg wet-wt).
Executive summary:

The bioconcentration factor of amyl cinnamic aldehyde was estimated by QSAR. the QSAR was carried out using BCFBAF v3.01 and a measured log Kow value of 4.7 (Rudio, 1994). The following equation was used:

log BCF= 0.6598 log Kow - 0.333 + correction

No correction factor was calculated by BCFBAF v3.01. The log BCF was estimated to be 2.768 (BCF = 586.2 L/kg wet-wt).

Due to the readily biodegradable nature of amyl cinnamic aldehyde, exposure to the aquatic environment is likely to be limited. The readily biodegradable nature of the substance will also mean that the BCF will be lower than that estimated from the log Kow of the substance, as it expected to be metabolised by aquatic microorganisms.

Description of key information

The log BCF was estimated to be 2.768 (BCF= 586.2 L/kg wet-wt).

Key value for chemical safety assessment

BCF (aquatic species):
586.2 L/kg ww

Additional information

The bioconcentration factor of amyl cinnamic aldehyde was estimated by QSAR. The QSAR was carried out using BCFBAF v3.01 and a measured log Kow value of 4.7 (Rudio, 1994). The following equation was used:

log BCF= 0.6598 log Kow - 0.333 + correction

No correction factor was calculated by BCFBAF v3.01. The log BCF was estimated to be 2.768 (BCF = 586.2 L/kg wet-wt).