Registration Dossier
Registration Dossier
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EC number: 242-604-9 | CAS number: 18824-74-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 24 Hour exposure period
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data review as part of the US National Toxicity Program (NTP) and considered reliable.
Data taken from review of anhydride, showing that the acid (hydride) quickly forms on ingestion.
Together with other weight of evidence, it is concluded that further animal testing cannot be justified
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Remarks:
- Performed 1964
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tetrabromophthalic anhydride
- EC Number:
- 211-185-4
- EC Name:
- Tetrabromophthalic anhydride
- Cas Number:
- 632-79-1
- Molecular formula:
- C8Br4O3
- IUPAC Name:
- Tetrabromophthalic anhydride
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Remarks:
- Hydrated form
- Duration of exposure:
- 24 hours,occlusive
- Doses:
- 1 - 10 g/kg
- No. of animals per sex per dose:
- Not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was reported
- Clinical signs:
- Animals showed depressed righting and placement reflexes at highest dose levels
There was no sign of dermal irritation - Other findings:
- No other findings reported
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Data review as part of the US National Toxicity Program (NTP) and considered reliable. The substance is concluded to be of low irritation and low toxicity in contact with the skin.
Data taken from review of anhydride, showing that the acid (hydride) quickly forms on ingestion.
Together with other weight of evidence, it is concluded that further animal testing cannot be justified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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