Dipotassium 3,4,5,6-tetrabromophthalate

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

key study

Study period:

72 hours

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

EPA review document covering tetrabromophthalates.
Substance in test was an alkyl ester, shown to react in light to quickly hydrolyse in water to the acid. The data relates to the acid form.
This is considered a valid substitute for read-across as the potassium salt will quickly dissociate; when diluted in solution, both the potassium salt and acid will combine with Calcium and Magnesium ions in natural water and form poorly soluble salts.

Data source

Reference

Reference Type:

publication

Title:

TSCA Work Plan Chemical Technical Supplement – Physicochemical Properties and Environmental Fate of the Brominated Phthalates Cluster (BPC) Chemicals

Author:

United States Environmental Protection Agency

Year:

2015

Bibliographic source:

EPA Document# 740-Q1-4001

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 201 (Alga, Growth Inhibition Test)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Tetrabromophthalic acid

Cas Number:

13810-83-8

Molecular formula:

C8H2Br4O4

IUPAC Name:

Tetrabromophthalic acid

Specific details on test material used for the study:

Substance in test was an alkyl ester, shown to react in light to quickly hydrolyse in water to the acid. The data relates to the acid form.
Bis(2-ethylhexyl) tetrabromophthalate, EC 247-426-5 hydrolysis shows rapid degradation to tetrabromophthalic acid ( Source: European Chemicals Agency, http://echa.europa.eu/)

This is considered a valid substitute for read-across as the potassium salt will quickly dissociate; when diluted in solution, both the potassium salt and acid will combine with Calcium and Magnesium ions in natural water and form poorly soluble salts.

Sampling and analysis

Analytical monitoring:

not specified

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

72 h

Results and discussion

Effect concentrations

Duration:

72 h

Dose descriptor:

EC0

Effect conc.:

> 5 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Details on results:

Only headline results were available in the review doucment.
The results were based on no effect at limit of solublity which is established to be ca 5 mg/l in the hard water used for algal tests.

Applicant's summary and conclusion

Conclusions:

Only headline results were available in the review doucment.
The results were based on no effect at limit of solublity which is established to be ca 5 mg/l in the hard water used for algal tests.
EPA review document covering tetrabromophthalates.
Substance in test was an alkyl ester, shown to react in light to quickly hydrolyse in water to the acid. The data relates to the acid form.
This is considered a valid substitute for read-across as the potassium salt will quickly dissociate; when diluted in solution, both the potassium salt and acid will combine with Calcium and Magnesium ions in natural water and form poorly soluble salts.