Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-711-2 | CAS number: 689-67-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.13/14 (Mutagenicity - Reverse Mutation Test Using Bacteria)
- GLP compliance:
- yes
- Remarks:
- Department of Toxicology, BASF Aktiengesellschaft
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 6,10-dimethylundeca-5,9-dien-2-one
- EC Number:
- 211-711-2
- EC Name:
- 6,10-dimethylundeca-5,9-dien-2-one
- Cas Number:
- 689-67-8
- Molecular formula:
- C13H22O
- IUPAC Name:
- 6,10-dimethylundeca-5,9-dien-2-one
- Details on test material:
- - Name of test material (as cited in study report): Geranylaceton
- Test substance No.: 97/3019
- Date of manufacture: December 4, 1996
- Physical state: Yellow liquid
- Analytical purity: 95.6 area%
- Lot/batch No.: PN.-Nr. 008626
- Storage condition of test material: Refrigerator
- Stability under test conditions: The stability of the test substance throughout the study period was not determined analytically. However, the characterization was performed from July 11, 1997 to August 21, 1997, indicating a stability of about 8 months after date of manufacture.
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor 1254-induced rat liver S-9 mix
- Test concentrations with justification for top dose:
- 0, 15, 20, 30, 60, 100, 125, 250, 500, 2500 and 5000 µg/plate
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: DMSO
- Justification for choice of solvent/vehicle: Due to the limited solubility af the test substance in water, DMSO was selected as the vehicle, which had
been demonstrated to be suitable in bacterial reverse mutation tests and for which historical control data are available.
Controlsopen allclose all
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- other: 2-aminoanthracene; 2.5 µg/plate, dissolved in DMSO (TA 1535, TA 100, TA 1537, TA 98)
- Remarks:
- with metabolic activation
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- other: 2-aminoanthracene; 60 µg/plate, dissolved in DMSO (E. coli WP2 uvrA)
- Remarks:
- with metabolic activation
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- N-ethyl-N-nitro-N-nitrosoguanidine
- Remarks:
- without metabolic activation
Migrated to IUCLID6: 5 µg/plate, dissolved in DMS0 (TA 1535, TA 100)
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- other: 4-nitro-o-phenylendiamine; 10 µg/plate, dissolved in DMSO (TA 98)
- Remarks:
- without metabolic activation
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- Remarks:
- without metabolic activation
Migrated to IUCLID6: 100 µg/plate, dissolved in DMSO (TA 1537)
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- N-ethyl-N-nitro-N-nitrosoguanidine
- Remarks:
- without metabolic activation
Migrated to IUCLID6: 10 µg/plate, dissolved in DMSO ( E. coli WP2 uvrA)
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation)
- The experimental procedure of the standard plate test (plate incorporation method) is based an the method of Ames et al. (1975)
DURATION
- Exposure duration: 48 - 72 h, 37°C
- Expression time (cells in growth medium): 48 - 72 h, 37°C
NUMBER OF REPLICATIONS: 3
DETERMINATION OF CYTOTOXICITY
- Method: decrease in the number of revertants, clearing or diminution of the background lawn (= reduced his- or trp- background growth), reduction in the titer - Evaluation criteria:
- The test chemical is considered positive in this assay if the following criteria are met:
- A dose-related and reproducible increase in the number of revertant colonies, i.e. about doubling of the spontaneous mutation rate in at least one
tester strain either without S-9 mix or after adding a metabolizing system.
A test substance is generally considered nonmutagenic in this test if:
- The number of revertants for all tester strains were within the historical negative control range under all experimental conditions in two experiments carried out independently of each other.
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- TA 100, TA1537: >250 µg/plate; TA 98, TA 1535: > 500
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Species / strain:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- ADDITIONAL INFORMATION ON CYTOTOXICITY:
- A bacteriotoxic effect (reduced his- background growth, decrease in the number of his+ revertants,
reduction in the titer) was observed depending an the strain and test conditions from about 250 µg - 500 µg/plate onward. - Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Results:
mean number of revertant colonies / plate | |||||||||||||||||
Strain | metabolic activation | Experiment | controls | µg substance / plate | Evaluation | ||||||||||||
negative | solvent | positive | 15 | 20 | 30 | 60 | 100 | 125 | 250 | 500 | 2500 | 5000 | |||||
TA 1535 | - | 1 | 20 | 1037 | 15 | 17 | 8 | 5B | 4B | - | |||||||
- | 2 | 18 | 1050 | 20 | 18 | 14 | 7B | 5B | - | ||||||||
- | 3 | 19 | 937 | 18 | 16 | 11 | 3B | 3B | - | ||||||||
+ | 1 | 17 | 228 | 19 | 21 | 15 | 14B | 4B | - | ||||||||
+ | 2 | 21 | 224 | 20 | 15 | 10 | 14B | 6B | - | ||||||||
+ | 3 | 23 | 204 | 18 | 19 | 13 | 11B | 10B | - | ||||||||
TA 1537 | - | 1 | 9 | 725 | 8 | 7 | 0B | 0B | 0B | - | |||||||
- | 2 | 10 | 805 | 8 | 5 | 0B | 0B | 0B | - | ||||||||
- | 3 | 9 | 801 | 8 | 7 | 0B | 0B | 0B | - | ||||||||
+ | 1 | 11 | 112 | 8 | 7 | 0B | 0B | 0B | - | ||||||||
+ | 2 | 10 | 100 | 10 | 7 | 0B | 0B | 0B | - | ||||||||
+ | 3 | 9 | 98 | 7 | 8 | 0B | 0B | 0B | - | ||||||||
TA 1537 | - | 1 | 10 | 661 | 10 | 9 | 7 | 6 | 3 | - | |||||||
- | 2 | 9 | 725 | 9 | 10 | 5 | 4 | 5 | - | ||||||||
- | 3 | 11 | 692 | 10 | 5 | 6 | 5 | 6 | - | ||||||||
+ | 1 | 10 | 176 | 7 | 8 | 9 | 6 | 3 | - | ||||||||
+ | 2 | 7 | 155 | 8 | 7 | 6 | 7 | 3 | - | ||||||||
+ | 3 | 12 | 169 | 10 | 8 | 7 | 6 | 4 | - | ||||||||
TA 98 | - | 1 | 26 | 1206 | 23 | 27 | 14 | 10B | 4B | - | |||||||
- | 2 | 26 | 1173 | 24 | 21 | 14 | 7B | 5B | - | ||||||||
- | 3 | 21 | 1112 | 25 | 21 | 13 | 11B | 7B | - | ||||||||
+ | 1 | 37 | 1304 | 41 | 27 | 20 | 17B | 10B | - | ||||||||
+ | 2 | 35 | 1377 | 34 | 33 | 18 | 13B | 5B | - | ||||||||
+ | 3 | 40 | 1299 | 31 | 30 | 19 | 12B | 5B | - | ||||||||
TA 100 | - | 1 | 113 | 1206 | 94 | 105 | 37B | 0B | 0B | - | |||||||
- | 2 | 124 | 1118 | 84 | 104 | 22B | 0B | 0B | - | ||||||||
- | 3 | 102 | 1112 | 84 | 100 | 12B | 0B | 0B | - | ||||||||
+ | 1 | 104 | 1064 | 107 | 101 | 0B | 0B | 0B | - | ||||||||
+ | 2 | 117 | 1036 | 105 | 102 | 0B | 0B | 0B | - | ||||||||
+ | 3 | 120 | 1074 | 99 | 89 | 0B | 0B | 0B | - | ||||||||
TA 100 | - | 1 | 100 | 1142 | 115 | 114 | 106 | 100 | 91 | - | |||||||
- | 2 | 103 | 857 | 99 | 84 | 101 | 104 | 72 | - | ||||||||
- | 3 | 110 | 976 | 113 | 100 | 121 | 101 | 88 | - | ||||||||
+ | 1 | 103 | 1294 | 135 | 92 | 120 | 100 | 80 | - | ||||||||
+ | 2 | 103 | 1037 | 106 | 121 | 98 | 127 | 70 | - | ||||||||
+ | 3 | 126 | 1169 | 114 | 119 | 104 | 101 | 62 | - | ||||||||
E. coli WP2 uvrA | - | 1 | 31 | 829 | 33 | 37 | 36 | 33 | 38 | - | |||||||
- | 2 | 31 | 876 | 30 | 39 | 35 | 27 | 29 | - | ||||||||
- | 3 | 36 | 913 | 33 | 35 | 30 | 32 | 31 | - | ||||||||
+ | 1 | 39 | 286 | 42 | 35 | 37 | 31 | 30 | - | ||||||||
+ | 2 | 45 | 300 | 42 | 35 | 39 | 35 | 32 | - | ||||||||
+ | 3 | 37 | 287 | 38 | 42 | 44 | 35 | 40 | - |
B: reduced backround growth
- the sterility controls revealed no indication of bacterial contamination
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.