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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented publication/ study report which meets basic scientific principles
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
other company data
Title:
Unnamed
Year:
1978
Report date:
1978
Reference Type:
secondary source
Title:
Acute toxicity studies on 6,10-dimethyl-5,9-undecadien-2-one
Author:
BASF AG
Year:
2008
Bibliographic source:
RIFM database
Report date:
1978

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Federal Register 38 No 187 §1500.41 (Haut) und §1500.42 (Auge), S. 27019 vom 27.09.73.
Principles of method if other than guideline:
Method: acc. Draize Test (1959)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
6,10-dimethylundeca-5,9-dien-2-one
EC Number:
211-711-2
EC Name:
6,10-dimethylundeca-5,9-dien-2-one
Cas Number:
689-67-8
Molecular formula:
C13H22O
IUPAC Name:
6,10-dimethylundeca-5,9-dien-2-one
Details on test material:
- Name of test material (as cited in study report): Geranylaceton R
- Substance No.: 77/274
- Analytical purity: min. 99%

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact and scarified
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): 100%
Duration of treatment / exposure:
24 h
Observation period:
8 days
Number of animals:
6; 4 male and 2 female
Details on study design:
TEST SITE
- Area of exposure: 2.5x2.5 cm, no further data given

SCORING SYSTEM:

Erythema and edema:
1 = questionable
2 = slight
3 = moderate to severe
4 = severe


Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24, 72 h
Score:
3
Max. score:
4
Reversibility:
not reversible
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24, 72 h
Score:
2.1
Max. score:
4
Reversibility:
not reversible

Any other information on results incl. tables

Single values from animals 1 - 6:

Readings Animal intact skin scarified skin
Erythema Edema Additional findings Erythema Edema Additional findings
24 h 1 3 3   3 o 3 o  
2 3 2   3 o 2 o  
3 3 2   3 o 2 o  
4 3 o 3 o   3 o 3 o  
5 3 o 2 o   3 o 2 o  
6 3 o 3 o   3 o 3 o  
72 h 1 3 2   3 o 3 o  
2 3 o 2 o   3 o 2 o  
3 3 o 3 o   3 o 3 o  
4 3 o 0 o i   3 o 0 o i  
5 3 o 2 o   2 o 2 o  
6 3 o 2 S 3 o 2 o  
8 d 1 2 o 2 S 2 o 2 sS
2 2 o 2 S 2 o 2 sS
3 # #   # #  
4 2 o 0 o i sS 3 o 0 o i sS
5 2 o 0 sS 2 o 0 sS
6 2 o 2 sS 2 o 2 sS
mean 24 - 72 h 1 3 2.5   3 3  
2 3 2   3 2  
3 3 2   3 2.5  
4 3 1.5   3 1.5  
5 3 2   2.5 2  
6 3 2.5   3 2.5  
mean 24 - 72 h   3.0 2.1   2.9 2.3  

# animal was sacrified on day 4 due to paralysis of hindlegs

o: overlapping area of application

S: scaling

sS: severe scaling

i: indurated

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU