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EC number: 203-253-7
CAS number: 104-93-8
Ear swelling was observed on day 6 before sacrifice in the animal
treated with 100% test item concentration and the ear thickness
measurement on day 6 showed an ear swelling of approximately 28% in
comparison to the measurement on day 1 prior to
No deaths occurred during the study period. No symptoms of local
irritation at the ears of the animals and no signs of systemic toxicity
were observed during the study period. The body weight of the animals,
recordedprior to the first application
and prior to treatment with3HTdR, was within the
range commonly recorded for animals of this strain and age.
A statistically significant increase in lymph node weights was not
observed in any of the test item treated groups in comparison to the
vehicle control group. A statistically significant increase in ear
weights was not observed in in any of the test item treated groups in
comparison to the vehicle control group.
Test item concentration % (w/v)
number of lymph nodes
DPM per lymph nodeb
BG = Background ( 1 mL 5% trichloroacetic acid) in duplicate
1 = Control Group
2 -4 = Test Group
S.I. = Stimulation Index
a) = The mean value was taken from the figures BG I
and BG II
b) = Since the lymph nodes of the animals of a dose
group were pooled, DPM/node was determined by dividing the measured
value by the number of lymph nodes pooled
The EC3 value could not be calculated, since
none of the tested concentrations induced an S.I. greater than 3.
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