Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report Date:
1971

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Remarks:
GLP was not compulsory at the time the study was conducted.
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): p-Methylanisole
- Analytical purity: no data given

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
The test material was administered as a 50 % (w/v or v/v) solution or suspension in corn oil.
Doses:
preliminary test: 5000 mg/kg bw
main study: 1000-6810 mg/kg bw (6 dose groups). Not further specified.
No. of animals per sex per dose:
5 animals per dose in the main study, 2 animals in the preliminary test
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 920 mg/kg bw
95% CL:
1 510 - 2 450
Mortality:
At 5000 mg/kg bw (preliminary test) 2/2 animals died. No further data given.
Clinical signs:
Pretest (5000 mg/kg bw): Bloody crust nose; diarrhea; depression; ataxia; hypopnea; lacrimation; salivation
Main test: dead rats showed darkened firm lungs

Applicant's summary and conclusion