Registration Dossier
Registration Dossier
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EC number: 203-253-7 | CAS number: 104-93-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Available as short summary from secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Metabolism of ethers in the rabbit. 2. Nuclear-substituted anisoles.
- Author:
- H.G. Bray, V.M. Craddock and W.V. Thorpe
- Year:
- 1 955
- Bibliographic source:
- Biochemical Journal, 60, 225-232; cited in RIFM/FEMA database Location 23121
Materials and methods
- Principles of method if other than guideline:
- Assessment of metabolisation in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-methylanisole
- EC Number:
- 203-253-7
- EC Name:
- 4-methylanisole
- Cas Number:
- 104-93-8
- Molecular formula:
- C8H10O
- IUPAC Name:
- 1-methoxy-4-methylbenzene
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Route of administration:
- oral: gavage
- Details on dosing and sampling:
- METABOLITE CHARACTERISATION STUDIES
Urine was collected for 24 hours
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- The greater part of a dose of p-methylanisole is oxidized to anisic acid; about 27% is, however, demethylated & excreted mainly as p-cresol. Anisic acid is excreted mainly as ester glucuronide & anisuric acid.
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