4-methylanisole

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Available as short summary from secondary source

Data source

Reference

Reference Type:

secondary source

Title:

Metabolism of ethers in the rabbit. 2. Nuclear-substituted anisoles.

Author:

H.G. Bray, V.M. Craddock and W.V. Thorpe

Year:

1955

Bibliographic source:

Biochemical Journal, 60, 225-232; cited in RIFM/FEMA database Location 23121

Materials and methods

Principles of method if other than guideline:

Assessment of metabolisation in rabbits

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

4-methylanisole

EC Number:

203-253-7

EC Name:

4-methylanisole

Cas Number:

104-93-8

Molecular formula:

C8H10O

IUPAC Name:

1-methoxy-4-methylbenzene

Test animals

Species:

rabbit

Administration / exposure

Route of administration:

oral: gavage

Details on dosing and sampling:

METABOLITE CHARACTERISATION STUDIES
Urine was collected for 24 hours

Results and discussion

Metabolite characterisation studies

Metabolites identified:

yes

Details on metabolites:

The greater part of a dose of p-methylanisole is oxidized to anisic acid; about 27% is, however, demethylated & excreted mainly as p-cresol. Anisic acid is excreted mainly as ester glucuronide & anisuric acid.