Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Available as short summary from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Metabolism of ethers in the rabbit. 2. Nuclear-substituted anisoles.
Author:
H.G. Bray, V.M. Craddock and W.V. Thorpe
Year:
1955
Bibliographic source:
Biochemical Journal, 60, 225-232; cited in RIFM/FEMA database Location 23121

Materials and methods

Principles of method if other than guideline:
Assessment of metabolisation in rabbits
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit

Administration / exposure

Route of administration:
oral: gavage
Details on dosing and sampling:
METABOLITE CHARACTERISATION STUDIES
Urine was collected for 24 hours

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
The greater part of a dose of p-methylanisole is oxidized to anisic acid; about 27% is, however, demethylated & excreted mainly as p-cresol. Anisic acid is excreted mainly as ester glucuronide & anisuric acid.

Applicant's summary and conclusion