Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-253-7 | CAS number: 104-93-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Available as short summary from secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Metabolism of ethers in the rabbit. 2. Nuclear-substituted anisoles.
- Author:
- H.G. Bray, V.M. Craddock and W.V. Thorpe
- Year:
- 1 955
- Bibliographic source:
- Biochemical Journal, 60, 225-232; cited in RIFM/FEMA database Location 23121
Materials and methods
- Principles of method if other than guideline:
- Assessment of metabolisation in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-methylanisole
- EC Number:
- 203-253-7
- EC Name:
- 4-methylanisole
- Cas Number:
- 104-93-8
- Molecular formula:
- C8H10O
- IUPAC Name:
- 1-methoxy-4-methylbenzene
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Route of administration:
- oral: gavage
- Details on dosing and sampling:
- METABOLITE CHARACTERISATION STUDIES
Urine was collected for 24 hours
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- The greater part of a dose of p-methylanisole is oxidized to anisic acid; about 27% is, however, demethylated & excreted mainly as p-cresol. Anisic acid is excreted mainly as ester glucuronide & anisuric acid.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
