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EC number: 203-253-7
CAS number: 104-93-8
The administration of 1000 mg/kg and 2000 mg/kg body weight
p-Cresolmethylether led to clinical signs of toxicity at both sacrifice
intervals. Clinical signs of toxicity in test animals were piloerection
and squatting posture in both dose groups after 14 h and a poor general
state in animals of the high dose group after 14 h. However, no reduced
viability of hepatocytes as indication for test substance induced
toxicity was observed.
In both parts of the study, the mean net nuclear grain counts per animal
of the test substance treated dose groups (-1.97 to -4.09) were close to
the respective vehicle control values (-2.31 to -5.17). In addition, the
mean values of the net nuclear grain counts of the test substance treated
dose groups (-2.48 to -3.32) were close to the respective vehicle
control values (-3.68 to -3.83) and within our historical negative
control data range (-1.96 to -7.92)
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