Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Remarks:
percutaneous
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1959
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1959
Report Date:
1959

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
not specified

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
single dose, percutaneous
Duration of exposure:
24 h
Doses:
undiluted
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 1 600 mg/kg bw
Based on:
test mat.
Mortality:
not specified
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Conclusions:
The LD50 of 2-methylfuran was determined to be 1600 mg/kg bw in a single dose acute dermal toxicity study in rabbits.
Executive summary:

In an acute dermal toxicity study in rabbits 2-methylfuran was administered by a single dermal application (percutaneous). Animals were exposed 24h to the undiluted substance. No further details on the study design were given and it was not specified if any guideline was followed.

The LD50 was determined to be 1600 mg/kg bw in this acute dermal toxicity study. The test substance was rated as moderately toxic by the authors of the study.