Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-600-9 | CAS number: 13863-31-5
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Remarks:
- other: five days.
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Unsuitable test system (only 5 consecutive days).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
- Report date:
- 1956
Materials and methods
- Principles of method if other than guideline:
- The effect of the 5 -days repeated skin administration to five rats was evaluated. 20 mg were given to each animal.
- GLP compliance:
- no
- Remarks:
- Pre GLP.
Test material
- Reference substance name:
- Disodium 4,4'-bis[[6-anilino-4-[(2-hydroxyethyl)methylamino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate
- EC Number:
- 237-600-9
- EC Name:
- Disodium 4,4'-bis[[6-anilino-4-[(2-hydroxyethyl)methylamino]-1,3,5-triazin-2-yl]amino]stilbene-2,2'-disulphonate
- Cas Number:
- 13863-31-5
- Molecular formula:
- C38H40N12Na2O8S2
- IUPAC Name:
- disodium 2,2'-ethene-1,2-diylbis[5-({4-anilino-6-[(2-hydroxyethyl)(methyl)amino]-1,3,5-triazin-2-yl}amino)benzenesulfonate]
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: gum arabic
- Details on exposure:
- TEST SITE
- Area of exposure: back.
TEST MATERIAL
- Amount applied: 0.4 ml
- Concentration: 5 %
- Constant volume or concentration used: yes. - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 5 days.
- Frequency of treatment:
- Daily.
Doses / concentrations
- Dose / conc.:
- 20 mg/kg bw/day (nominal)
- Remarks:
- Doses / Concentrations:
20 mg/animal
Basis:
no data
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Results of examinations
- Details on results:
- After 8 days no abnormalities detected.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 20 other: mg/animal
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: no effects up to the highest dose
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- After 8 days no abnormalities detected in animals exposed to 20 mg of the test substance.
- Executive summary:
Method
The effect of the 5 -days repeated skin administration to five rats was evaluated. 20 mg were given to each animal.
Result
After 8 days no abnormalities detected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
