Registration Dossier
Registration Dossier
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EC number: 201-849-1 | CAS number: 88-66-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-chloro-2-(dichloromethyl)benzene
- EC Number:
- 201-849-1
- EC Name:
- 1-chloro-2-(dichloromethyl)benzene
- Cas Number:
- 88-66-4
- Molecular formula:
- C7H5Cl3
- IUPAC Name:
- 1-chloro-2-(dichloromethyl)benzene
- Details on test material:
- Purity > 99%
Impurities: 2-chlorobenzyl chloride and 2-chlorobenzotrichloride each < 0.2%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund
- Age at study initiation: no data
- Weight at study initiation: 3.2 - 3.6 kg
- Housing: individually
- Diet: Altromin 2013 ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 2 °C
- Humidity (%): 55 +/- 10 %
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.5 ml undiluted
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 7 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 6.25 cm²
- Type of wrap if used: semiocclusive bandage
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 hours
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
Any other information on results incl. tables
| Animal | Symptom | Time after patch removal | ||||
| No. | ||||||
| 30 - 60 | 24 | 48 | 72 | 7 | ||
| min | h | h | h | d | ||
| 1 | erythema | 2 | 2 | 2 | 2 | 0 |
| 1 | edema | 0 | 0 | 0 | 0 | 0 |
| 2 | erythema | 0 | 1 | 2 | 2 | 0 |
| 2 | edema | 1 | 0 | 0 | 0 | 0 |
| 3 | erythema | 1 | 1 | 2 | 2 | 0 |
| 3 | edema | 0 | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Conclusions:
- Based on the results of this study 2-chlorobenzal chloride is not irritating to skin.
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